Chloramphenicol Palmitate

COMPOSITION:

Each 5ml contains:
ChloramphenicolPalmitate
Eq. to Chloramphenicol BP 125mg

INDICATIONS:

It is effective against typhoid and broad –spectrum bacterial (Gram-positive and Gram-negative) diseases. Chloramphenicol Palmitate is a dichloroacetic acid derivative. Chloramphenicol is a broad-spectrum antibiotic and is bacteriostatic. Chloramphenicol is hydrolysed in the upper intestinal tract into the parent drug. It is lipid soluble, diffuses through the bacterial cell membrane and reversibly binds to the 50 S subunit of bacterial ribosomes where transfer of amino acids to growing peptide chains is prevented, thus inhibiting peptide bond formation and subsequent protein synthesis.

Dosage and Administration:

• For oral dosage forms (capsules and suspension):
o Adults and teenagers—Dose is based on body weight. The usual dose is 12.5 milligrams (mg) per kilogram (kg) (5.7 mg per pound) of body weight every six hours.
o Children— Infants up to 2 weeks of age: Dose is based on body weight. The usual dose is 6.25 mg per kg (2.8 mg per pound) of body weight every six hours. Infants 2 weeks of age and older: Dose is based on body weight. The usual dose is 12.5 mg per kg (5.7 mg per pound) of body weight every six hours; or 25 mg per kg (11.4 mg per pound) of body weight every twelve hours.

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